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Updated: Mar 26, 2026

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
Published on: June 10, 2018
Pluripotent Stem Cells: Current Understanding and Future Directions.
Antonio Romito1, Gilda Cobellis2
1Centogene, Schillingallee 68, 18057 Rostock, Germany.
Pluripotent stem cells (PSCs) can renew themselves and form all body cells. Distinct PSC states and induced PSCs share and differ in features, expanding the definition of pluripotency.
Area of Science:
- Stem cell biology
- Developmental biology
- Cellular reprogramming
Background:
- Pluripotent stem cells (PSCs) are defined by self-renewal and differentiation potential.
- Recent discoveries reveal distinct PSC states complicating this definition.
- Understanding these states is crucial for regenerative medicine and developmental studies.
Purpose of the Study:
- To provide a comprehensive overview of pluripotent cell lines.
- To compare embryonic-derived PSCs (from mouse and human) with induced PSCs (iPSCs).
- To identify shared and distinct features that define pluripotency.
Main Methods:
- Comparative analysis of established pluripotent cell lines.
- Review of literature on embryonic stem cells and induced pluripotent stem cells.
- Characterization of cellular states and pluripotency hallmarks.
Main Results:
- Embryonic-derived PSCs and iPSCs exhibit both common and unique characteristics.
- These findings expand the established hallmarks of pluripotency.
- Distinct cellular states within pluripotency are identified and described.
Conclusions:
- The definition of pluripotency is more complex than previously thought.
- A comprehensive understanding of PSC states is essential.
- This work offers a detailed scenario of the pluripotent stem cell family.
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