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Updated: Feb 8, 2026

Formulation and Characterization of Bioactive Agent Containing Nanodisks
Published on: March 17, 2023
Diverse Molecular Targets for Chalcones with Varied Bioactivities
1Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, USA.
Abstract:
Natural or synthetic chalcones with different substituents have revealed a variety of biological activities that may benefit human health. The underlying mechanisms of action, particularly with respect to the direct cellular targets and the modes of interaction with the targets, have not been rigorously characterized, which imposes challenges to structure-guided rational development of therapeutic agents or chemical probes with acceptable target-selectivity profile. This review summarizes literature evidence on chalcones' direct molecular targets in the context of their biological activities.
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