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Triazole antifungals: a review
L R Peyton1, S Gallagher1, M Hashemzadeh2
1University of Arizona and Pima College, Tucson, Arizona, USA.
Drugs of Today (Barcelona, Spain : 1998)
|January 23, 2016
Summary
This review discusses the rising threat of invasive fungal infections and antifungal resistance. It highlights how second-generation triazole antifungals offer improved treatments over older medications.
Area of Science:
- Medical Mycology
- Medicinal Chemistry
Background:
- Invasive fungal infections and systemic mycosis are increasing globally.
- Treatment challenges include drug resistance, organ dysfunction, and safety concerns with existing antifungals.
Purpose of the Study:
- To review the development and properties of triazole-derived antifungal agents.
- To highlight advancements in treating invasive fungal infections.
Main Methods:
- Literature review of scientific publications on triazole antifungals.
- Analysis of the chemical structures and therapeutic profiles of triazole derivatives.
Main Results:
- Triazole compounds exhibit potent antifungal properties.
- Second-generation triazoles (e.g., voriconazole, posaconazole) were developed to address limitations of earlier agents like itraconazole and fluconazole.
Conclusions:
- Triazole antifungals represent a critical class of drugs for managing invasive fungal infections.
- Ongoing research into triazole derivatives is essential to combat emerging antifungal resistance.
Keywords:
AlbaconazoleAzoleCYP51Cytochrome P450EfinaconazoleFluconazoleInvasive fungal infectionIsavuconazoleIsavuconazonium sulfateItraconazoleLanosterol 14α-demethylasePosaconazoleRavuconazoleTriazoleVoriconazoleMore Related Videos
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