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Typhoid perforation.

E J Gibney1

  • 1Beaumont Hospital, Dublin, Ireland.

The British Journal of Surgery
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Typhoid bowel perforation is a serious condition common in developing nations, leading to high mortality rates. This review covers its causes, diagnosis, and treatment strategies.

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Area of Science:

  • Gastroenterology
  • Surgical Pathology
  • Infectious Diseases

Background:

  • Typhoid perforation of the bowel is a significant surgical challenge, particularly in resource-limited settings.
  • It is associated with substantial morbidity and mortality.

Purpose of the Study:

  • To review the pathogenesis of typhoid perforation.
  • To discuss current diagnostic approaches.
  • To outline management strategies for this condition.

Main Methods:

  • Literature review of typhoid perforation.
  • Synthesis of information on pathogenesis, diagnosis, and management.

Main Results:

  • Typhoid perforation results from Salmonella Typhi infection leading to intestinal wall necrosis and rupture.

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  • Diagnosis relies on clinical suspicion, imaging, and laboratory tests.
  • Management involves prompt surgical intervention, often with ileostomy or resection and anastomosis, alongside appropriate antibiotic therapy.

    • Conclusions:

    • Effective management requires early diagnosis and surgical intervention.
    • Understanding pathogenesis aids in prevention and treatment.
    • Multidisciplinary care improves outcomes for patients with typhoid perforation.