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Elusive Reaction Intermediates in Solution Explored by ESI-MS: Reverse Periscope for Mechanistic Investigations
Claudio Iacobucci1, Samantha Reale1, Francesco De Angelis2
1Dipartimento di Scienze Fisiche e Chimiche, Università dell'Aquila, Via Vetoio, Coppito, 67100, L'Aquila, Italy.
Abstract:
Just as periscopes allow a submarine to visually search for objects above the surface of the sea, in a reversed periscope fashion electrospray mass spectrometry (ESI-MS) can analyze the compounds at the gas phase/liquid phase interface for chemical entities which may exist in solution. The challenge is the identification and structural characterization of key elusive reaction intermediates in chemical transformations, intermediates which are able to explain how chemical processes occur. This Minireview summarizes recent selected publications on the use of ESI-MS techniques for studying solution intermediates of homogeneous chemical reactions.
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