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Urinary incontinence in men: current and developing therapy options.

Helena Burden1, Paul Abrams2

  • 1a Urology SPR , Southmead Hospital , Bristol, UK.

Expert Opinion on Pharmacotherapy
|January 23, 2016
PubMed
Summary
This summary is machine-generated.

Urinary incontinence in men, often linked to overactive bladder (OAB), can be treated with medications like antimuscarinics and β3 agonists. These therapies are effective and show no increased urinary retention risk in men with benign prostatic obstruction.

Keywords:
Urinary incontinenceantimuscarinicmaleoveractive bladder

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Area of Science:

  • Urology
  • Pharmacology

Background:

  • Male urinary incontinence is a prevalent issue, encompassing urgency and stress types.
  • Urgency incontinence often presents as part of overactive bladder (OAB) syndrome, frequently co-occurring with benign prostatic obstruction (BPO).

Purpose of the Study:

  • To review synthetic drugs used in treating male urinary incontinence.
  • Focus on medications in phase III trials and beyond.

Main Methods:

  • Literature review of synthetic drugs for male urinary incontinence.
  • Exclusion of neurological incontinence and surgical treatments.

Main Results:

  • Antimuscarinics and β3 agonists are effective pharmacotherapies for OAB.
  • These treatments do not increase urinary retention risk in patients with co-existing BPO.

Conclusions:

  • Urgency incontinence due to OAB, often with bladder outflow obstruction (BOO), is common in men.
  • Emerging treatments include solabegron and ritobegron, with potential for novel combination therapies.