Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A human gallbladder adenocarcinoma cell line.

H Johzaki1, H Iwasaki, T Nishida

  • 1Department of Pathology, Fukuoka University School of Medicine, Japan.

Cancer
|December 1, 1989
PubMed
Summary

A new gallbladder adenocarcinoma cell strain, FU-GBC-1, was established from patient ascites. This well-differentiated cell line provides a valuable model for studying gallbladder cancer biology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Induction of angiotensin converting enzyme and angiotensin II receptors in the atherosclerotic aorta of high-cholesterol fed Cynomolgus monkeys.

Atherosclerosis·1998
Same author

Supernumerary ring chromosomes and nuclear blebs in some low-grade malignant soft tissue tumours: atypical lipomatous tumours and dermatofibrosarcoma protuberans.

Virchows Archiv : an international journal of pathology·1998
Same author

Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning.

Genes to cells : devoted to molecular & cellular mechanisms·1998
Same author

Reirradiation therapy for brain metastases from small cell lung cancer.

Radiation medicine·1998
Same author

Remission induction by granulocyte colony-stimulating factor in hypoplastic acute myelogenous leukemia complicated by infection. A case report and review of the literature.

Acta haematologica·1998
Same author

[The efficacy of low-dose propofol for intrathecal morphine-induced pruritus].

Masui. The Japanese journal of anesthesiology·1998

Area of Science:

  • Oncology
  • Cell Biology
  • Gastroenterology

Background:

  • Gallbladder adenocarcinoma is a significant malignancy with limited treatment options.
  • The lack of well-characterized cell lines hinders research into gallbladder cancer's biology and treatment.

Observation:

  • A novel cell strain, FU-GBC-1, was derived from the ascites of a patient with well-differentiated gallbladder adenocarcinoma.
  • Microscopic analysis revealed adenocarcinoma features, including gland-like structures and mucous production.
  • Immunoperoxidase staining confirmed expression of tumor antigens CA 19-9, CEA, and EMA.

Findings:

  • The FU-GBC-1 cell strain demonstrated stable culture characteristics for over 1.5 years.
  • Cytogenetic analysis indicated a loss of chromosome Y and aneuploidy (4C DNA content).

Related Experiment Videos

  • Inoculation into nude mice resulted in transplantable adenocarcinoma, mirroring the original tumor.

    • Implications:

    • The FU-GBC-1 cell strain represents a unique, well-differentiated model for gallbladder adenocarcinoma research.
    • This new cell line can facilitate studies on the morphology and biology of gallbladder cancer.
    • It may aid in developing novel diagnostic and therapeutic strategies for this disease.