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Related Experiment Videos

Hepatic resection for secondary tumours.

L I Nudelmann1, R Cabot, I S Benjamin

  • 1Universitätsklinik fur Viszerale und Transplantationschirurgie, Bern, Switzerland.

Cancer Surveys
|January 1, 1989
PubMed
Summary

Liver resection for secondary colorectal cancer shows promising survival rates, with up to 50% five-year survival post-operation. This contrasts with historical data, establishing resection as a key treatment for colorectal secondaries.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Hepatobiliary Surgery

Background:

  • Liver metastases significantly impact survival in colorectal cancer patients.
  • Historically, surgical intervention for liver secondaries was limited due to perceived poor outcomes.
  • The efficacy of liver resection for secondary tumors, particularly from colorectal cancer, warrants detailed review.

Purpose of the Study:

  • To review the role and outcomes of liver resection for secondary tumors, focusing on colorectal cancer.
  • To evaluate survival data comparing resection versus non-resection for liver metastases.
  • To identify prognostic factors influencing survival after liver resection for secondary malignancies.

Main Methods:

  • Review of existing literature and clinical series on liver resection for secondary tumors.
  • Analysis of survival data, particularly five-year survival rates, in patients with and without resection.
  • Identification of factors associated with adverse outcomes post-resection.

Main Results:

  • While controlled trials are lacking, numerous series report up to 50% five-year survival after liver resection for colorectal secondaries.
  • Five-year survival without resection has fallen to approximately 5% in major series.
  • Poor tumor clearance, metastasis number, and potentially Dukes' C primary tumors adversely affect survival.

Conclusions:

  • Liver resection is increasingly established as a treatment for colorectal cancer liver metastases.
  • Factors like extent of resection and tumor size may impact perioperative outcomes but not long-term survival.
  • Resectional treatment may also be considered for select non-colorectal secondary tumors, such as endocrine tumors.

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