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Heart acceleration and deceleration capacities associated with dilated cardiomyopathy

Cao Zou1, Hongkai Dong1, Fengyan Wang1

  • 1Cardiology Department, First Affiliated Hospital of Soochow University, Suzhou, China.

European Journal of Clinical Investigation
|January 24, 2016
PubMed

Insights

Heart rate acceleration capacity and deceleration capacity are independent risk factors for dilated cardiomyopathy (DCM). Acceleration capacity also predicts heart failure worsening in DCM patients.

Area of Science:

  • Cardiology
  • Autonomic Nervous System Research
  • Cardiac Electrophysiology

Background:

  • Heart rate deceleration capacity and acceleration capacity are emerging indicators of cardiac neural regulation.
  • Dilated cardiomyopathy (DCM) affects cardiac electrophysiology, but its relationship with these autonomic indices is not well understood.

Purpose of the Study:

  • To investigate the association between heart rate acceleration capacity, deceleration capacity, and DCM.
  • To determine if these autonomic markers are independent risk factors for DCM.

Main Methods:

  • A study involving 66 DCM patients and 209 controls.
  • Collection of demographic, echocardiographic, and heart rate variability data, including deceleration capacity and acceleration capacity.
  • Analysis using multiple logistic regression to assess the association patterns.

Main Results:

  • Deceleration capacity (OR 7.97) and acceleration capacity (OR 0.09) were identified as independent risk factors for DCM.
  • Acceleration capacity, fastest heart rate, and left ventricular ejection fraction (LVEF) were associated with heart failure grade.
  • Acceleration capacity (OR 1.32) and LVEF (OR 0.46) remained independent predictors of heart failure severity.

Conclusions:

  • Heart rate acceleration capacity and deceleration capacity are significant independent risk factors for DCM.
  • Acceleration capacity serves as a predictive marker for heart failure exacerbation in individuals with DCM.
Abstract

Keywords:
Dilated cardiomyopathyelectrophysiologyheart rate acceleration capacityheart rate deceleration capacity

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