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Incidence and Clinical Course of Respiratory Viral Coinfections in Children Aged 0-59 Months

A Nitsch-Osuch1, E Kuchar2, A Topczewska-Cabanek3

  • 1Department of Family Medicine, Warsaw Medical University, 1A Banacha St., 02-097, Warsaw, Poland. anitsch@wum.edu.pl.

Advances in Experimental Medicine and Biology
|January 24, 2016
PubMed

Insights

Coinfections involving multiple respiratory viruses were found in 8% of young children. However, these coinfections did not significantly alter the clinical course of respiratory tract infections compared to single-virus cases.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Respiratory medicine

Background:

  • Coinfections with multiple respiratory viruses are common in children.
  • Existing data on coinfection impact on disease severity is contradictory.
  • Understanding coinfection patterns is crucial for pediatric respiratory illness management.

Purpose of the Study:

  • To investigate the prevalence of viral coinfections in young children with respiratory tract infections.
  • To identify common viral combinations in pediatric coinfections.
  • To assess if coinfections influence the clinical severity of respiratory illness.

Main Methods:

  • 114 children aged 0-59 months with respiratory symptoms were enrolled.
  • Nasal and pharyngeal swabs were tested using PCR for 12 common respiratory viruses.
  • Coinfection cases were identified and analyzed for viral combinations and clinical presentation.

Main Results:

  • Coinfections were detected in 9 (8%) of the 114 patients.
  • Influenza A (H3N2) was involved in five coinfection cases with various other viruses.
  • Other coinfections involved combinations such as adenovirus/hCoVOC43 and RSV A/PIV-1.
  • No significant differences in clinical course were observed between single and multiple viral infections.

Conclusions:

  • Viral coinfections occur in a small percentage of young children with respiratory tract infections.
  • Commonly identified coinfections involved influenza A and other respiratory viruses.
  • The presence of multiple viruses did not lead to more severe clinical outcomes in this cohort.

Keywords:
ChildrenCoinfectionEtiologyPathogenesis of infectionRespiratory tract diseaseVirus

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