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Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
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microRNAs in Psoriasis

Jason E Hawkes1, Giang Huong Nguyen2, Mayumi Fujita2

  • 1Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.

The Journal of Investigative Dermatology
|January 24, 2016
PubMed

Insights

MicroRNAs are small molecules that regulate gene expression and are increasingly recognized for their role in psoriasis pathogenesis. This review details their function in this chronic inflammatory skin condition.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Psoriasis is a chronic inflammatory skin disease with complex pathogenesis.
  • The exact mechanisms underlying psoriasis development are not fully understood.
  • microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression.

Purpose of the Study:

  • To provide a comprehensive review of microRNAs.
  • To elucidate the role of microRNAs in the pathogenesis of psoriasis.

Main Methods:

  • Literature review of current research on microRNAs and psoriasis.
  • Analysis of studies investigating miRNA expression and function in psoriatic skin.

Main Results:

  • Accumulating evidence highlights the involvement of specific miRNAs in psoriasis.
  • MicroRNAs influence key pathways in keratinocyte and immune cell function relevant to psoriasis.
  • Dysregulation of miRNAs contributes to the inflammatory processes in psoriasis.

Conclusions:

  • MicroRNAs are critical regulators in the pathogenesis of psoriasis.
  • Targeting microRNAs presents a potential therapeutic strategy for psoriasis.
  • Further research is needed to fully understand miRNA networks in psoriasis.

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