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Updated: Mar 26, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Perinatal Major Depression Biomarkers: A systematic review.

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Perinatal depression affects 15% of new mothers, impacting social function. Research is exploring biological biomarkers to understand its causes and prevent intergenerational transmission of risks to offspring.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Reproductive Medicine

Background:

  • Perinatal depression, including postpartum depression, affects up to 15% of mothers.
  • It is linked to significant social dysfunction and has complex risk factors like psychosocial stress.
  • Onset typically occurs during late pregnancy or the postpartum period, posing a major health concern.

Purpose of the Study:

  • To review current biological biomarkers associated with perinatal depression pathogenesis.
  • To highlight the impact of suboptimal prenatal environments on offspring development and mother-child bonding.
  • To explore the concept of intergenerational transmission of parental biological changes to offspring.

Main Methods:

  • Literature review of existing research on perinatal depression biomarkers.
  • Analysis of studies investigating psychosocial stress and biological pathways.
  • Examination of evidence for intergenerational transmission mechanisms.

Main Results:

  • Biological pathways underlying perinatal depression are increasingly being explored.
  • Suboptimal prenatal environments can lead to lasting harm to offspring.
  • Parental biological changes can influence offspring via gametes and the uterine environment.

Conclusions:

  • Identifying reliable biomarkers in high-risk mothers is crucial for preventing perinatal depression.
  • Understanding these biomarkers can mitigate risks for both mother and child.
  • Early detection and intervention are key to improving maternal and child well-being.