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Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone
Camilo D Seabra Pereira1, Luciane A Maranho2, Fernando S Cortez3
1Departamento de Ciências do Mar, Universidade Federal de São Paulo, Av. Saldanha da Gama n.89, 11030-400 Santos, SP, Brazil; Laboratório de Ecotoxicologia, Universidade Santa Cecília, Rua Oswaldo Cruz 266, 11045-907 Santos, SP, Brazil.
Abstract:
The present study determined environmental concentrations of pharmaceuticals, cocaine, and the main human metabolite of cocaine in seawater sampled from a subtropical coastal zone (Santos, Brazil). The Santos Bay is located in a metropolitan region and receives over 7367m(3) of wastewater per day. Five sample points under strong influence of the submarine sewage outfall were chosen. Through quantitative analysis by LC-MS/MS, 33 compounds were investigated. Seven pharmaceuticals (atenolol, acetaminophen, caffeine, losartan, valsartan, diclofenac, and ibuprofen), an illicit drug (cocaine), and its main human metabolite (benzoylecgonine) were detected at least once in seawater sampled from Santos Bay at concentrations that ranged from ng·L(-1) to μg·L(-1). In light of the possibility of bioaccumulation and harmful effects, the high concentrations of pharmaceuticals and cocaine found in this marine subtropical ecosystem are of environmental concern.