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Updated: Mar 26, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Outcomes of 1000 Carotid Wallstent Implantations: Single-Center Experience
Sonia Ronchey1, Barbara Praquin2, Matteo Orrico1
1Department of Vascular Surgery, San Filippo Hospital, Rome, Italy.
Insights
Carotid artery stenting (CAS) using Wallstents is safe and effective for treating carotid artery disease, demonstrating low complication rates and restenosis. This study confirms CAS as a viable treatment option with excellent outcomes.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Neurology
Background:
- Carotid artery disease poses a significant risk of stroke.
- Carotid artery stenting (CAS) is an alternative to endarterectomy for managing carotid stenosis.
- Wallstents have been utilized for CAS, but long-term outcomes require evaluation.
Purpose of the Study:
- To assess the outcomes of carotid artery stenting (CAS) using Wallstents in a single-center cohort.
- To evaluate the safety and efficacy of CAS with Wallstents for various indications of carotid artery disease.
- To determine the incidence of adverse events, including stroke and restenosis, following CAS.
Main Methods:
- A retrospective analysis of 1000 CAS procedures performed between 2003 and 2013 using Carotid Wallstents.
- Patients treated for de novo lesions, post-surgical stenosis, or high surgical risk were included.
- Follow-up involved duplex ultrasound and clinical evaluation; radiography was used for suspected stent issues.
Main Results:
- Procedure success was high at 99.3%, with low 30-day adverse events (2.1%), including stroke (1.8%).
- Factors like plaque morphology and symptomatic status influenced postoperative neurologic events.
- Restenosis occurred in 3.2% at follow-up, associated with diabetes, smoking, and calcification; no stent fractures or migration were observed.
Conclusions:
- Carotid artery stenting (CAS) with Wallstents is a safe and effective treatment for carotid artery disease.
- The procedure demonstrates very low rates of major adverse events and neurologic complications.
- Wallstents show excellent results even with complex plaque and low restenosis rates.
Purpose:
To evaluate the outcomes of carotid artery stenting (CAS) with Wallstents in a single-center experience.
Methods:
From January 2003 to December 2013, 1000 carotid artery lesions were treated with Carotid Wallstents under cerebral protection in 877 patients (mean age 71.7 ± 8 years; 621 men). Indications for treatment were de novo lesions (>70% asymptomatic and >60% symptomatic); stenoses following carotid endarterectomy, radiation, or neck surgery; contralateral laryngeal nerve palsy; and high surgical risk. All the patients underwent duplex ultrasound and clinical evaluation during follow-up; radiography was performed when fracture or stent migration was suggested by ultrasound.
Results:
Procedure success was achieved in 99.3% of patients. Major and minor 30-day adverse events occurred in 2.1% of patients, including stroke (1.8%: 1.3% minor, 0.5% major), myocardial infarction (0.1%), and death (0.2%). Plaque morphology, nature of stenosis, and symptomatic status were significantly associated with the risk of postoperative neurologic events. Restenosis occurred in 3.2% at a mean 45.5-month follow-up and was significantly associated with diabetes, smoking, symptomatic stenosis, de novo stenosis, and calcification (plaque III/IV). No fracture or migration was registered during follow-up.
Conclusion:
CAS is a valid method for treating carotid artery disease, with very low rates of major adverse events and neurologic complications. The Carotid Wallstent seems to have excellent results, even with complex plaque morphology, and a low incidence of restenosis at follow-up.
