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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Research progress on the reproductive and non-reproductive endocrine tumors by estrogen-related receptors

Zhixiang Xu1, Jun Liu1, Lipeng Gu1

  • 1Faulty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, Yunnan, China.

The Journal of Steroid Biochemistry and Molecular Biology
|January 24, 2016
PubMed

Insights

Estrogen-related receptors (ERRs) are increasingly linked to various cancers, including reproductive and non-reproductive tumors. Understanding ERRs

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Estrogen receptors (ERs) are traditionally linked to tumorigenesis.
  • Estrogen-related receptors (ERRs) share structural similarities with ERs.
  • ERRs are emerging as potential factors in both reproductive and non-reproductive endocrine tumors.

Purpose of the Study:

  • To introduce different subtypes and structures of ERRs.
  • To describe ERRs expression patterns in various cancers.
  • To discuss the role of ERRs in tumorigenesis for potential therapeutic strategies.

Main Methods:

  • Literature review of ERRs
  • Analysis of ERRs expression in gynecological cancers (breast, endometrial, ovarian)
  • Examination of ERRs in male genitourinary cancers (prostate) and other tumors (lung, colorectal, liver)

Main Results:

  • Detailed introduction to ERRs subtypes and structures.
  • Comprehensive overview of ERRs expression across diverse cancer types.
  • Discussion on the involvement of ERRs in the processes of tumorigenesis.

Conclusions:

  • ERRs are implicated in a wide range of cancers.
  • Further research into ERRs may offer novel avenues for cancer prevention and treatment.
  • This review provides a foundation for understanding ERRs in oncology.
Keywords:
Estrogen receptorEstrogen-related receptorsNon-reproductive endocrine tumorsReproductive endocrine tumorstumor prevention

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