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Related Concept Videos

Bioplastics01:27

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Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers
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A robust super-tough biodegradable elastomer engineered by supramolecular ionic interactions.

Hamed Daemi1, Sareh Rajabi-Zeleti2, Haritz Sardon3

  • 1Department of Polyurethane, Iran Polymer & Petrochemical Institute, Tehran, Iran; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute, Tehran, Iran.

Biomaterials
|January 25, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed alginate-based supramolecular ionic polyurethanes (ASPUs) that are strong, tough, and tunable biomaterials. These metal-free elastomers show excellent mechanical properties, self-healing, and biocompatibility for tissue engineering applications.

Keywords:
AlginateBiodegradationLoad-bearing tissueSelf-healingSupramolecular elastomerVascular tissue engineering

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Polymer Chemistry

Background:

  • Developing mechanically robust and tunable biomaterials is crucial for tissue engineering.
  • Existing materials often require metal catalysts or lack sufficient strength and toughness in hydrated states.
  • Alginate-based polymers offer potential due to their biocompatibility and abundance.

Purpose of the Study:

  • To develop novel alginate-based supramolecular ionic polyurethanes (ASPUs) under metal-free conditions.
  • To investigate the mechanical properties, including tunability, strength, toughness, and cyclic performance, of ASPUs.
  • To evaluate the biocompatibility, biodegradability, self-healing capabilities, and in vivo response of ASPUs.

Main Methods:

  • Synthesis of alginate-based supramolecular ionic polyurethanes (ASPUs) using metal-free conditions.
  • Mechanical testing to determine Young's modulus, tensile strength, hysteresis, and cyclic loading response.
  • In vitro and in vivo biocompatibility and degradation studies, including histological analysis.
  • Assessment of self-healing and recovery properties after rupture.

Main Results:

  • ASPUs were successfully synthesized with tunable Young's modulus (30-100 MPa) and tensile strength (20-50 MPa).
  • Materials exhibited minimal hysteresis, creep, and strength loss over 100 cycles, outperforming linear polyurethanes.
  • ASPUs demonstrated rapid self-healing, linear biodegradation comparable to polycaprolactone (PCL), and low in vivo immunological response and fibrosis.

Conclusions:

  • Metal-free ASPUs represent a new class of mechanically tunable, high-performance biomaterials.
  • Their exceptional cyclic stability, biocompatibility, and biodegradability make them promising for load-bearing tissue engineering.
  • ASPUs offer a versatile platform for advanced regenerative medicine applications.