[Analysis of Chemotherapy with Trastuzumab in Advanced Gastric Cancer]
Junji Kawada1, Rie Nakatsuka, Masaaki Motoori
1Dept. of Gastroenterological Surgery, Osaka General Medical Center.
Purpose:
Here, we investigated the efficacy of chemotherapy with trastuzumab for patients with advanced or recurrent gastric cancer.
Materials And Methods:
We investigated the progression free survival (PFS) and overall survival (OS) of advanced gastric cancer patients who received first-line chemotherapy with trastuzumab in our hospital.
Result:
After first-line chemotherapy, the median PFS and median OS of patients who received trastuzumab combined with capecitabine/cisplatin chemotherapy was not significantly longer than those of patients who received trastuzumab combined with S-1/cisplatin chemotherapy (PFS, 138 [95%CI: 118-187] vs 169 [95%CI: 83-251] days, p=0.9684; OS, 393 [95%CI: 240-469] vs 466 [95%CI: 256-482] days, p=0.4703). After second-line chemotherapy, the median PFS of patients who received trastuzumab plus irinotecan chemotherapy was not significantly longer than that of patients who received trastuzumab plus paclitaxel chemotherapy (PFS, 63 [95%CI: 52-266] vs 58 [95%CI: 26-184] days, p=0.5447).
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