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Related Concept Videos

Sensory Functions of the Skin01:16

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Staphylococcal Skin Infections01:29

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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Sensitive skin.

L Misery1, K Loser2, S Ständer3

  • 1Department of Dermatology, University Hospital, Brest, France.

Journal of the European Academy of Dermatology and Venereology : JEADV
|January 26, 2016
PubMed
Summary
This summary is machine-generated.

Sensitive skin involves facial sensations like stinging and burning, potentially linked to nerve fibers and environmental triggers. This review explores its causes, symptoms, and treatments.

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Area of Science:

  • Dermatology and Neuroscience

Background:

  • Sensitive skin is characterized by self-reported facial sensations such as tightness, stinging, burning, tingling, pain, and pruritus.
  • It can occur independently, with skin barrier impairment, or alongside dermatological conditions like rosacea, atopic dermatitis, and psoriasis.

Purpose of the Study:

  • To review current knowledge on the epidemiology, potential mechanisms, clinical presentation, and therapeutic options for sensitive skin.

Main Methods:

  • This study is a review of existing literature on sensitive skin.
  • It synthesizes information regarding the underlying physiological and environmental factors.

Main Results:

  • Symptoms suggest involvement of cutaneous nerve fibers, neuronal, and epidermal thermochannels, particularly TRPV1.
  • Environmental factors may exacerbate symptoms, possibly via TRPV1 activation.
  • Skin barrier disruptions and immune mechanisms are also implicated.

Conclusions:

  • Sensitive skin is a complex condition with multifactorial origins, likely involving neurosensory pathways and environmental interactions.
  • Further experimental studies are needed to elucidate the precise mechanisms and guide effective therapies.