Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

124.6K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
124.6K
Spermatogenesis01:22

Spermatogenesis

10.8K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
10.8K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

3.0K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
3.0K
Testes: Histology01:27

Testes: Histology

3.6K
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
3.6K
Testes: Gross Anatomy01:19

Testes: Gross Anatomy

8.2K
The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
8.2K
Infertility in Males01:23

Infertility in Males

680
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
680

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic characterization of <i>bla</i><sub>IMP</sub>-harboring plasmids in <i>Klebsiella</i> spp.

Microbiology spectrum·2026
Same author

Cross-National Differences in Mental Health Impact of Intergenerational Caregiving: Social Pathways Among Older Women in China and the US.

Clinical gerontologist·2026
Same author

Folic acid alleviates heat stress-induced ovarian dysfunction in dairy cows via modulation of follicular fluid metabolism and ABC transporter activity.

Animal reproduction science·2026
Same author

Dihydroartemisinin, a novel YTHDF2 inhibitor, alleviates rheumatoid arthritis by suppressing neutrophil extracellular traps via an autophagy-dependent pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

EEF1B2 interacts with KATNA1 to potentiate microtubule severing and neurite outgrowth.

Neuroscience·2026
Same author

Benzo[a]pyrene exacerbates bone destruction by inhibiting Treg differentiation, impairing Treg function and promoting osteoclastogenesis in rats with collagen-induced arthritis.

Ecotoxicology and environmental safety·2026

Related Experiment Video

Updated: Mar 26, 2026

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
11:11

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes

Published on: February 8, 2016

23.7K

Testicular immunoregulation and spermatogenesis.

Qiaoyuan Chen1, Tingting Deng2, Daishu Han1

  • 1Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.

Seminars in Cell & Developmental Biology
|January 26, 2016
PubMed
Summary

The mammalian testis has a unique immune privilege protecting germ cells. Local innate immune responses defend against microbes, maintaining testicular immune homeostasis crucial for fertility.

Keywords:
Immune privilegeInfertilityInnate immune responsesOrchitisTestis

More Related Videos

An In Vivo Method to Study Mouse Blood-Testis Barrier Integrity
05:48

An In Vivo Method to Study Mouse Blood-Testis Barrier Integrity

Published on: December 2, 2018

11.9K
A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

16.0K

Related Experiment Videos

Last Updated: Mar 26, 2026

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
11:11

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes

Published on: February 8, 2016

23.7K
An In Vivo Method to Study Mouse Blood-Testis Barrier Integrity
05:48

An In Vivo Method to Study Mouse Blood-Testis Barrier Integrity

Published on: December 2, 2018

11.9K
A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

16.0K

Area of Science:

  • Reproductive Immunology
  • Innate Immunity
  • Male Reproductive Biology

Background:

  • The mammalian testis is an immunoprivileged site, shielding germ cells from immune attack.
  • Despite immune privilege, the testis must defend against microbial pathogens.
  • Understanding testicular immune regulation is vital for reproductive health.

Purpose of the Study:

  • To review current knowledge on testicular immunoregulation.
  • To explore the interplay between immune privilege and innate immunity in the testis.
  • To discuss the impact of testicular immune homeostasis on spermatogenesis and male infertility.

Main Methods:

  • Literature review of studies on testicular immune privilege.
  • Analysis of pattern recognition receptor-initiated innate immune responses in testicular cells.
  • Synthesis of findings on immunoregulatory mechanisms and their effects.

Main Results:

  • The testis employs effective local innate immune responses to combat microbial infections.
  • Coordination between immune privilege and innate immunity maintains testicular immune homeostasis.
  • Disruption of this homeostasis can lead to orchitis and impaired spermatogenesis.

Conclusions:

  • Testicular immune homeostasis is critical for normal spermatogenesis and male fertility.
  • Further dissection of testicular immunoregulatory mechanisms can inform treatments for orchitis.
  • Understanding these mechanisms is key to addressing male infertility causes.