Related Experiment Video
Updated: Mar 26, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
20.1K
Multidisciplinary Approach for Acromegaly: A Single Tertiary Center's Experience
Ozlem Haliloglu1, Enis Kuruoglu2, Hande Mefkure Ozkaya1
1Division of Endocrinology-Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
World Neurosurgery
|January 26, 2016
Summary
Acromegaly remission rates after surgery were 51.5% early and 75.2% late. Factors like sellar floor invasion and high Ki-67 negatively impacted disease control, highlighting the need for multidisciplinary care.
Area of Science:
- Endocrinology
- Neurosurgery
- Oncology
Background:
- Acromegaly is a complex disease requiring a multidisciplinary treatment strategy.
- Surgical outcomes and factors influencing remission are crucial for patient management.
Purpose of the Study:
- To assess early and late remission rates in acromegaly patients post-transsphenoidal surgery.
- To identify correlations between adenoma characteristics, treatment modalities, and remission success.
Main Methods:
- Retrospective review of 103 acromegaly patients undergoing endoscopic endonasal transsphenoidal surgery (2007-2014).
- Analysis of clinical, biochemical, radiological, and pathological data.
- Evaluation of factors affecting early and late remission.
Main Results:
- Overall late remission rate was 75.2% (early: 51.5%).
- Sellar floor invasion was linked to poorer early and late remission.
- Higher Ki-67 (<3%) correlated with better late remission and lower reoperation rates.
- Medical therapy was required for 68.6% of patients during follow-up.
Conclusions:
- A multidisciplinary approach achieved 75.2% late remission in acromegaly patients.
- Younger age, male sex, high Ki-67, and tumor invasion negatively impacted disease control.
- Sellar floor and cavernous sinus invasion are significant predictors of poor outcomes.
