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07:39
Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
Published on: June 8, 2016
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2-Nitrobenzyl Borate Based Photolabile Linker for Breakable Polymer Vesicles
Ruidong Cheng1, Jiangang Chen1, Zhaotie Liu1
1Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi, 710062, P. R. China.
Macromolecular Rapid Communications
|January 26, 2016
Summary
Researchers synthesized a photosensitive poly(ethylene glycol)-lipid (NP-B-PEG) for controlled drug release. Upon UV irradiation, it releases doxorubicin (DOX) in two stages, offering a novel drug delivery system.
Area of Science:
- Polymer Chemistry
- Organic Synthesis
- Materials Science
Background:
- Photolabile groups are crucial in synthetic and biological chemistry.
- Developing efficient photosensitive materials is an ongoing area of research.
Purpose of the Study:
- To synthesize and characterize a novel photosensitive poly(ethylene glycol)-lipid (NP-B-PEG).
- To investigate the controlled release of doxorubicin (DOX) from NP-B-PEG upon UV irradiation.
Main Methods:
- Synthesis of NP-B-PEG with a 2-nitrobenzyl 2-pyridinylmethyl borate hydrophobic tail.
- Characterization using (1)H-NMR and absorption spectroscopy.
- Phototriggered drug release experiments with doxorubicin.
Main Results:
- NP-B-PEG demonstrated rapid photocleavage of the nitrobenzyl borate upon 365 nm irradiation.
- Doxorubicin (DOX) release occurred in two stages: slow leakage followed by rapid precipitation.
- Borate hydrolysis was retarded by DOX loading but accelerated upon vesicle disintegration.
Conclusions:
- The synthesized NP-B-PEG acts as a photosensitive drug delivery system.
- UV irradiation triggers a two-stage release of doxorubicin.
- This system offers potential for controlled and targeted drug delivery applications.
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