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Updated: Mar 26, 2026

Spinal Cord Neurons Isolation and Culture from Neonatal Mice
Published on: July 11, 2017
Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
Murat Sahin1, Huriye Gullu2, Kemal Peker3
1Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Amasya, Amasya, Turkey.
Abstract:
The neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 µg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia.
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