Related Experiment Video
Updated: Mar 26, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
Long non-coding RNA derived miR-205-5p modulates human endometrial cancer by targeting PTEN
Weijuan Xin1, Xiaoxia Liu1, Jingxin Ding1
1Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University Shanghai 200032, China.
Objective:
This study was to investigate the roles of lncRNA associated competitive endogenous RNAs (ceRNAs) network in the endometrial cancer (EC).
Methods:
StarbaseV2.0 online software was used to predict the most probable lncRNAs which contain miR-205-5p binding site and are competent to interact with miR-205-5p. Then, lncRNAs which had decreased expression in EC compared with normal endometrium and conformed to the polyadenylated characteristics of lncRNAs were selected and then lncRNAs associated with miR-205-5p-PTEN network were identified.
Results:
Two novel genes RP11-395G23.3 and LA16c-313D11.11 associated with endometrial cancer were identified and proved to be non-coding RNAs. They were more effective ceRNAs associated with the miR-205-5p-PTEN network.
Conclusion:
Our results suggest that lncRNAs harbor MREs (miRNA response elements) and play important roles in the post-transcriptional regulation in EC.
Related Concept Videos
MicroRNAs
MicroRNAs
lncRNA - Long Non-coding RNAs
Abnormal Proliferation
piRNA - Piwi-interacting RNAs
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

