A preliminary study on the relationship between circulating tumor cells count and clinical features in patients with
Jia-Wei Wan1, Ming-Zhu Gao1, Rong-Jun Hu1
11 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China ; 3 Shanghai Genosaber Biotech Co. Ltd, Shanghai 200001, China.
Background:
To evaluate the clinical value of circulating tumor cells (CTC) count in peripheral venous blood of patients with non-small cell lung carcinoma (NSCLC).
Methods:
A total of 50 NSCLC patients who were diagnosed in Wuxi No. 2 People's Hospital from January 2013 to December 2013 were selected as the NSCLC group, 35 patients with lung benign tumor as the benign group, and 28 healthy subjects as the normal control group. Venous blood samples (3 mL) were collected in all subjects for counting the CTC, and a result of ≥8.7 was judged to be positive. The relationships between the positive rate of CTC and the age, sex, pathological type, and clinical stage of NSCLC were analyzed.
Results:
CTC count was significantly higher in NSCLC group than in benign group and normal control group. In NSCLC patients, CTC count was not significantly correlated with sex, age, or the pathological type (P>0.05) but was closely related to clinical stage (P<0.01). Among NSCLC patients, CTC count significantly increased along with tumor progression.
Conclusions:
CTC count shows certain correlation with the clinical features of NSCLC and thus can, to certain extent, reflect the status of the disease.
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