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Is Long-Term Low-Dose Aspirin Therapy Associated with Renal Dysfunction in Patients with Type 2 Diabetes? JPAD2

Sadanori Okada1,2, Takeshi Morimoto3, Hisao Ogawa4

  • 1Department of Diabetology, Nara Medical University, Kashihara, Nara, Japan.

Plos One
|January 26, 2016
PubMed

Insights

Long-term low-dose aspirin use in type 2 diabetes patients does not harm kidney function. The study found no increased risk of renal dysfunction or changes in estimated glomerular filtration rate (eGFR) with aspirin treatment.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Cardiovascular disease (CVD) risk is high in diabetes patients.
  • Low-dose aspirin is recommended for CVD prevention, but its long-term renal effects in diabetes are unclear.

Purpose of the Study:

  • To investigate the long-term impact of low-dose aspirin on renal function in patients with type 2 diabetes.

Main Methods:

  • A randomized controlled trial (RCT), the JPAD trial, followed by a cohort study.
  • Patients with type 2 diabetes received either low-dose aspirin or no aspirin.
  • Evaluated incidence of positive urine dipstick albumin and annual changes in estimated glomerular filtration rate (eGFR).

Main Results:

  • Low-dose aspirin did not increase the incidence of positive urine dipstick albumin in intention-to-treat or on-treatment analyses.
  • No significant differences in annual eGFR changes were observed between aspirin and no-aspirin groups.
  • Factors like age, serum creatinine, HbA1c, and blood pressure influenced albuminuria risk, but not aspirin use.

Conclusions:

  • Long-term low-dose aspirin use is safe for renal function in type 2 diabetes patients.
  • Aspirin does not adversely affect eGFR or increase albuminuria in this population.
Abstract

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