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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Does elective parathyroidectomy for primary hyperparathyroidism affect renal function? A prospective cohort study.

Richard J Egan1, Ffion Dewi1, Rose Arkell1

  • 1Department of General Surgery, University Hospital of Wales, Heath Park, Cardiff, CF14 4XY, United Kingdom.

International Journal of Surgery (London, England)
|January 26, 2016
PubMed
Summary
This summary is machine-generated.

Elective parathyroid surgery can lead to post-operative renal impairment in a significant number of patients. A pre-operative risk score may help identify individuals susceptible to this kidney injury.

Keywords:
Acute kidney injuryParathyroidectomyPost-operative acute kidney injury

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Area of Science:

  • Nephrology
  • Endocrinology
  • Surgical Outcomes

Background:

  • Major surgical procedures are linked to acute kidney injury (AKI).
  • This study investigates the relationship between elective parathyroid surgery and subsequent renal impairment.

Purpose of the Study:

  • To assess post-operative renal function changes in patients undergoing elective parathyroidectomy.
  • To explore the utility of a pre-operative renal risk score in predicting renal impairment.

Main Methods:

  • Evaluation of consecutive patients undergoing elective parathyroidectomy.
  • Collection of demographic data and blood parameters.
  • Calculation of a pre-operative renal risk score for each patient.

Main Results:

  • Mean serum creatinine increased and estimated glomerular filtration rate (eGFR) decreased post-operatively.
  • 30.7% of patients showed a creatinine increase of ≥10% on post-operative day 1.
  • Patients with a ≥10% creatinine increase had a higher pre-operative renal risk score.

Conclusions:

  • A notable proportion of patients experience worsening renal function after elective parathyroid surgery.
  • Pre-operative risk stratification may identify patients at higher risk for post-operative renal impairment.