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Flow Synthesis in Hot Water: Synthesis of the Atypical Antipsychotic Iloperidone
Jan Hartwig1, Andreas Kirschning2
1Institut für Organische Chemie, und Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167, Hannover, Germany.
Abstract:
Inductively heated steel reactors continuously perform organic transformations in water under high temperature conditions, utilizing the unique physiochemical properties of water at subcritical conditions. We demonstrated the power of this set-up in the continuous synthesis of the atypical antipsychotic drug iloperidone, in which we performed four out of five steps under aqueous conditions.
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