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Related Experiment Video

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Inducement and Evaluation of a Murine Model of Experimental Myopia
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Altered functional connectivity density in high myopia.

Liying Zhai1, Qian Li2, Tianyue Wang1

  • 1School of Medical Imaging, Tianjin Medical University, Tianjin 300203, PR China.

Behavioural Brain Research
|January 26, 2016
PubMed
Summary
This summary is machine-generated.

High myopia (HM) is linked to altered brain functional connectivity (FC), particularly in areas related to attention. This study reveals decreased FC in HM individuals, potentially explaining attention deficits in myopia.

Keywords:
AttentionFunctional connectivity densityFunctional magnetic resonance imagingHigh myopiaRostrolateral prefrontal cortex

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Cognitive Science

Background:

  • High myopia (HM) is associated with abnormal visual experiences and attention deficits.
  • Previous research identified brain morphological changes in HM, but functional connectivity (FC) alterations remain unclear.

Purpose of the Study:

  • To investigate functional connectivity (FC) alterations in the brains of individuals with high myopia (HM).
  • To explore the relationship between FC changes and attention deficits in HM.

Main Methods:

  • Utilized resting-state functional connectivity density (FCD) mapping.
  • Employed seed-based correlation analysis to examine FC in HM.
  • Compared FC patterns between HM individuals and emmetropics.

Main Results:

  • HM individuals showed decreased short- and long-range FCD in the posterior cingulate cortex/precuneus.
  • Reduced long-range FCD was observed in the inferior temporal gyrus, supramarginal gyrus, and rostrolateral prefrontal cortex of HM.
  • Significant decrease in FC between the supramarginal gyrus and rostrolateral prefrontal cortex, and their respective networks (ventral attention and frontoparietal control networks) was found in HM.

Conclusions:

  • High myopia is associated with widespread functional connectivity alterations in the brain.
  • These FC changes, particularly in attention-related networks, may underlie the observed attention deficits in individuals with high myopia.
  • Findings provide crucial insights into the neurobiological underpinnings of myopia beyond visual acuity.