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Updated: Mar 26, 2026

An Epithelial Abrasion Model for Studying Corneal Wound Healing
Published on: December 29, 2021
PKM2 released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis
Yinwei Zhang1, Liangwei Li1, Yuan Liu1
1Department of Biology, Georgia State University, Atlanta, Georgia.
Abstract:
Neutrophils infiltration/activation following wound induction marks the early inflammatory response in wound repair. However, the role of the infiltrated/activated neutrophils in tissue regeneration/proliferation during wound repair is not well understood. Here, we report that infiltrated/activated neutrophils at wound site release pyruvate kinase M2 (PKM2) by its secretive mechanisms during early stages of wound repair. The released extracellular PKM2 facilitates early wound healing by promoting angiogenesis at wound site. Our studies reveal a new and important molecular linker between the early inflammatory response and proliferation phase in tissue repair process.
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