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Updated: Mar 26, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Serum endothelial cell specific molecule-1 (endocan) levels in patients with obstructive sleep apnea
Zuleyha Bingol1, Murat Kose2, Aylin Pıhtılı3
1Istanbul University, Istanbul Faculty of Medicine, Department of Pulmonary Medicine, 34360, Istanbul, Turkey.
Objective:
To investigate the level of endothelial cell specific molecule-1 (endocan) in obstructive sleep apnea (OSA).
Methods:
Study group included subjects with OSA. Control group included subjects who had no OSA on polysomnography and nonobese healthy subjects from population who had no OSA symptoms. Endocan levels of OSA and non-OSA subjects were compared.
Results:
Totally 106 individuals (63 OSA, 43 non-OSA) were included. Endocan levels were higher in OSA subjects than controls (1.25 ± 0.4 ng/ml vs 0.93 ± 0.3 ng/ml, p < 0.001). Endocan levels were correlated with BMI (r = 0.456, p < 0.001) and daytime PaO2 (r = -0.266, p < 0.042). In linear regression analysis there was no factor related to endocan level.
Conclusion:
Serum endocan is significantly higher in OSA. Further studies should be performed to better understand the relationship between endocan and OSA.
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