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Clinical evaluation of protein C: a comparative review of antigenic and functional assays

R A Marlar1, D M Adcock

  • 1Laboratory Service, Denver VA Medical Center, CO 80220.

Human Pathology
|November 1, 1989
PubMed

Insights

Protein C (PC) deficiency can cause serious blood clots. This review details laboratory tests for diagnosing PC deficiency, aiding clinical laboratories in accurate assessment.

Area of Science:

  • Clinical Biochemistry
  • Hematology
  • Diagnostic Laboratory Medicine

Background:

  • Thromboembolic disease is a significant complication of protein C (PC) deficiency.
  • PC deficiency is an increasingly recognized cause of hereditary thrombotic disease.
  • Accurate laboratory evaluation of PC is crucial for diagnosing this deficiency.

Purpose of the Study:

  • To review various clinical assays for protein C (PC) antigenic and activity levels.
  • To discuss the attributes and diagnostic value of different PC assay types.
  • To provide guidance for laboratories implementing PC assays.

Main Methods:

  • Review of existing literature on protein C (PC) assays.
  • Description of clinical antigenic assays for PC.
  • Description of protein C (PC) activity assays.

Main Results:

  • Different types of PC assays possess distinct attributes.
  • Specific assays are valuable for diagnosing acquired and hereditary PC deficiencies.
  • The review covers both antigenic and activity-based PC testing methods.

Conclusions:

  • Laboratory evaluation of protein C (PC) is essential for diagnosis.
  • Understanding assay attributes aids in selecting appropriate diagnostic methods.
  • This review serves as a guide for laboratories establishing PC testing protocols.

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