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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

108
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
108
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

226
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
226
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

149
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
149
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

249
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
249
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

85
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
85
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

94
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Engineering nanolayered particles for modular drug delivery.

Santiago Correa1, Erik C Dreaden2, Li Gu2

  • 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 26, 2016
PubMed
Summary

Layer-by-layer (LbL) self-assembly creates versatile nanoparticles for advanced nanomedicines. This technique enables multifunctional drug delivery systems with enhanced targeting and controlled release for various diseases.

Keywords:
Active targetingBiomaterialsClinical translationColloid chemistryCombination therapyControlled releaseDiagnosticsDrug deliveryGene deliveryLayer-by-layerNanoparticlesPolymer engineeringScalable synthesisShelf lifeTheranostics

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Layer-by-layer (LbL) self-assembly is a powerful technique for developing multifunctional nanoparticles.
  • This method allows for precise control over nanoparticle composition and architecture.
  • LbL assembly offers versatility in creating complex nanostructures for biomedical applications.

Purpose of the Study:

  • To review recent advancements in LbL nanoparticles for drug delivery and diagnostics.
  • To highlight the incorporation of key features like biostability, active targeting, and controlled drug release.
  • To discuss the potential of LbL nanomaterials for combination therapies and clinical translation.

Main Methods:

  • Sequential deposition of alternately charged polyelectrolytes onto colloidal templates.
  • Incorporation of diverse functional materials (nucleic acids, polymers, proteins) within multilayers.
  • Engineering of hierarchically complex, heterogeneous thin films on nanoscale templates.

Main Results:

  • LbL assembly enables high modularity, versatility, and compositional heterogeneity in nanoparticles.
  • Functional materials can be integrated to create sophisticated nanomedicines.
  • LbL nanoparticles can be engineered for systemic drug delivery with tunable properties.

Conclusions:

  • LbL-based self-assembly is a promising approach for developing advanced nanomedicines.
  • Further development focuses on enhancing biostability, targeting, drug release, and combination therapies.
  • These nanomaterials show significant potential for future clinical applications in disease treatment.