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Mapping minor H genes

E Simpson1, K Tomonari

  • 1MRC Clinical Research Centre, Transplantation Biology Section, Harrow, Middlesex, U.K.

Immunology. Supplement
|January 1, 1989
PubMed

The manner in which minor histocompatibility (H) antigens have been defined in mouse and man, in vivo and in vitro, is considered. Chromosomal mapping of minor H genes using T-cell clones is illustrated, with particular reference to the H-Y antigen gene, using the sex-reversing translocation Sxr of mouse and the Sxr' mutation derived from it. A number of minor H antigen-specific T-cell clones restricted by class I or class II major histocompatibility complex (MHC) molecules are described, together with information about their phenotypes and T-cell receptor usage.

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