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Related Experiment Video

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Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics
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Could "red cell distribution width" predict COPD severity?

K C Tertemiz1, A Ozgen Alpaydin1, C Sevinc1

  • 1Dokuz Eylul University Medical Faculty, Department of Pulmonary Diseases, Balcova, Izmir, Turkey.

Revista Portuguesa De Pneumologia
|January 27, 2016
PubMed
Summary
This summary is machine-generated.

Red blood cell distribution width (RDW) increases with chronic obstructive pulmonary disease (COPD) severity and is linked to poorer survival. RDW may serve as a biomarker for COPD assessment.

Keywords:
COPDInflammationRed blood cell distribution widthSurvival

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Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Biomarkers

Background:

  • Erythrocyte morphology is altered by systemic inflammation, ineffective erythropoiesis, and nutritional deficiencies.
  • Red blood cell distribution width (RDW) reflects erythrocyte morphology and size variability.
  • Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disease with significant morbidity and mortality.

Purpose of the Study:

  • To investigate the relationship between Red blood cell distribution width (RDW) and the severity of Chronic Obstructive Pulmonary Disease (COPD).
  • To assess the correlation of RDW with the BODE index, a multidimensional staging system for COPD.
  • To evaluate the association of RDW with survival outcomes in patients diagnosed with COPD.

Main Methods:

  • Retrospective analysis of medical records from 385 COPD patients.
  • Data collection included demographic features, BODE index components, and oxygen saturation.
  • Survival analysis was conducted up to 2014, with RDW values evaluated at study inclusion.

Main Results:

  • Red blood cell distribution width (RDW) showed significant differences across COPD stages, with the highest values in the very severe stage (p<0.001).
  • A positive correlation was observed between increasing BODE index and elevated RDW (p<0.001).
  • Patients with RDW >14.3% had a lower survival rate (31%) compared to those with RDW <14.3% (75%).

Conclusions:

  • Erythrocyte size variability, as indicated by RDW, increases with COPD severity.
  • Red blood cell distribution width (RDW) shows potential as a noninvasive biomarker for assessing COPD severity.
  • RDW appears to be correlated with survival in patients suffering from COPD.