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ABO blood group mismatched hematopoietic stem cell transplantation

Sibel Akpınar Tekgündüz1, Namık Özbek2

  • 1Pediatric Hematology and Oncology, Ankara Keçiören Training and Research Hospital, Ankara, Turkey.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|January 27, 2016
PubMed

Apart from solid organ transplantations, use of ABO-blood group mismatched (ABO-mismatched) donors is acceptable in hematopoietic stem cell transplantation (HSCT) patients. About 20-40% of allogeneic HSCT recipients will receive grafts from ABO-mismatched donors. ABO incompatible HSCT procedures are associated with immediate and late consequences, including but not restricted to acute or delayed hemolytic reactions, delayed red blood cell recovery, pure red cell aplasia and graft-versus-host disease. This review summarizes the current knowledge about consequences of ABO-mismatched HSCT in terms of associated complications and will evaluate its impact on important outcome parameters of HSCT.

Keywords:
ABO mismatchAllogeneic hematopoietic stem cell transplantationEngrafmentTransfusionTransplantation complications

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