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Mannose binding lectin codon 54 polymorphism and susceptibility to recurrent respiratory tract infections in

Ozlem Atan1, Ahmet Kucukcelebi2, Tahir Atik3

  • 1Acıbadem University, Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, Turkey.

International Journal of Pediatric Otorhinolaryngology
|January 27, 2016
PubMed
Abstract

Insights

This meta-analysis found no significant link between mannose binding lectin (MBL) gene variations and recurrent respiratory tract infections (RRTI) in children. Further research is needed to clarify MBL

Area of Science:

  • Immunogenetics
  • Pediatric Infectious Diseases
  • Molecular Epidemiology

Background:

  • Mannose binding lectin (MBL) plays a crucial role in the innate immune system.
  • Polymorphisms in the MBL gene have been investigated for their association with various infections, including recurrent respiratory tract infections (RRTI).
  • Previous studies on MBL gene polymorphism and RRTI susceptibility in children have yielded inconclusive results.

Purpose of the Study:

  • To conduct a meta-analysis to evaluate the association between MBL gene polymorphism at codon 54 and susceptibility to recurrent respiratory tract infections (RRTI) in children.
  • To synthesize existing evidence and provide a statistically robust conclusion on the MBL-RRTI relationship in pediatric populations.

Main Methods:

  • A systematic literature search was performed using Medline and PubMed databases.
  • Eligible studies included those determining MBL gene polymorphism at codon 54, reporting RRTI as an outcome in children, and having at least two comparison groups.
  • Odds ratios for MBL polymorphisms were calculated and combined; heterogeneity was assessed using Chi-squared testing (p<0.001).

Main Results:

  • Five eligible studies were included in this meta-analysis.
  • Significant heterogeneity was observed among the included studies (p=0.001).
  • The meta-analysis did not reveal any statistically significant association between MBL genotypes (AA, BB, AB) or alleles (A, B) and the risk of RRTI in children.

Conclusions:

  • This meta-analysis of published data indicates no statistically significant association between MBL2 genotype variations at codon 54 and recurrent respiratory tract infections in children.
  • The findings suggest that MBL polymorphism may not be a major determinant of RRTI susceptibility in the pediatric population.
  • Discrepancies in previous research highlight the complexity of host-pathogen interactions and the need for further investigation.
Keywords:
Mannose binding lectinPolymorphismRespiratory

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