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Antibodies to structural and nonstructural gag-coded proteins of type-D retroviruses in humans with lymphadenopathy

V A Morozov1, P O Ilyinskii, W A Uckert

  • 1All-Union Cancer Research Center AMS, Moscow, USSR.

International Journal of Tissue Reactions
|January 1, 1989
PubMed

The sera of patients with lymphadenopathies (children, suffering from primary immune deficiencies) and AIDS were analysed for the presence of antibodies against D-type retroviruses by means of radioimmunoprecipitation (RIP) and Western blotting. It was established that these sera contain the antibodies derived against p27, the major structural protein of type-D retroviruses, in a considerable percentage (12/80 for lymphadenopathy (LAP) patients and 9/12 for AIDS patients). Some serum samples reacted in RIP with Pr78gag, the precursor of gag-coded proteins of these viruses. The results obtained for AIDS patients are in contrast with those reported by other research groups. Nevertheless, it seems highly probable that D-type retroviruses are truly associated with human immunodeficiencies, as has been shown for simian ones.

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