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Updated: Mar 26, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Insights
Preventing pain in newborns is crucial, especially for premature infants in the NICU who face numerous painful procedures. Proven therapies for neonatal pain management are underused and should be implemented in all facilities.
Area of Science:
- Neonatal care
- Pediatric pain management
Background:
- Repeated painful exposures in neonates can lead to neurodevelopmental impairment.
- Premature infants, particularly the smallest and sickest, experience the most pain in the NICU.
- There are significant knowledge gaps in optimal neonatal pain prevention and relief strategies.
Purpose of the Study:
- To emphasize the ethical imperative and clinical necessity of neonatal pain prevention.
- To highlight the underutilization of existing, safe, and effective pain management therapies for neonates.
- To advocate for the implementation of comprehensive pain management programs in neonatal care settings.
Main Methods:
- Review of current practices and knowledge gaps in neonatal pain management.
- Identification of ethical considerations and potential consequences of unrelieved neonatal pain.
- Proposal of a two-part pain management program for healthcare facilities.
Main Results:
- Proven, safe therapies for neonatal pain are underused for routine procedures.
- Neonates at highest risk for neurodevelopmental impairment are exposed to the most painful stimuli.
- Effective pain prevention strategies are essential for vulnerable infants.
Conclusions:
- Healthcare facilities must implement pain prevention programs to minimize painful procedures.
- A robust pain assessment and management plan, including pharmacologic and nonpharmacologic therapies, is necessary.
- Systematic implementation of pain management protocols is vital for improving neonatal outcomes.
Abstract:
The prevention of pain in neonates should be the goal of all pediatricians and health care professionals who work with neonates, not only because it is ethical but also because repeated painful exposures have the potential for deleterious consequences. Neonates at greatest risk of neurodevelopmental impairment as a result of preterm birth (ie, the smallest and sickest) are also those most likely to be exposed to the greatest number of painful stimuli in the NICU. Although there are major gaps in knowledge regarding the most effective way to prevent and relieve pain in neonates, proven and safe therapies are currently underused for routine minor, yet painful procedures. Therefore, every health care facility caring for neonates should implement (1) a pain-prevention program that includes strategies for minimizing the number of painful procedures performed and (2) a pain assessment and management plan that includes routine assessment of pain, pharmacologic and nonpharmacologic therapies for the prevention of pain associated with routine minor procedures, and measures for minimizing pain associated with surgery and other major procedures.
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