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Lin28 and let-7 in the Metabolic Physiology of Aging

Elwin Tan Jun-Hao1, Renuka Ravi Gupta1, Ng Shyh-Chang1

  • 1Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.

Trends in Endocrinology and Metabolism: TEM
|January 27, 2016
PubMed

Insights

The Lin28/let-7 pathway controls cell growth and metabolism, impacting stem cells, aging, and diseases like cancer and cardiovascular conditions. This RNA regulation mechanism influences long-term epigenetic effects.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • The Lin28/let-7 pathway is a key regulator of growth signaling and metabolism.
  • This RNA regulatory mechanism is crucial in stem cells, development, aging, and cancer.

Purpose of the Study:

  • To review the Lin28/let-7 regulatory mechanism.
  • To explore its impact on various diseases and biological processes.

Main Methods:

  • Literature review of studies on Lin28/let-7.
  • Analysis of its role in cancer, cardiovascular diseases, growth GWAS, and metabolic diseases.

Main Results:

  • Lin28 reactivation is linked to cancers.
  • let-7 is implicated in cardiovascular diseases.
  • The pathway influences metabolic physiology and potentially epigenetic programming.

Conclusions:

  • The Lin28/let-7 pathway is a critical coordinator of cellular growth and metabolism.
  • It has significant implications for human health, disease, and potentially long-term epigenetic modifications.
Keywords:
Lin28cancercardiomyopathydiabeteslet-7metabolism

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