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Penetration of ceftazidime into intracranial abscess
H T Green1, M A O'Donoghue, M D Shaw
1Department of Microbiology, Walton Hospital, Liverpool, UK.
Abstract:
The penetration of ceftazidime into intracranial abscess was investigated in nine patients receiving intravenous ceftazidime. Concentrations of antibiotic in pus were measured by a microbiological agar diffusion assay (12 samples) and high performance liquid chromatography (8 samples) at varying times following ceftazidime administration. Concentrations of ceftazidime varying between 2.7 and 27.0 mg/l were detected. The role of ceftazidime in the therapy of intra-cranial abscess of otogenic origin is discussed.
Insights
Ceftazidime penetrates intracranial abscesses, with concentrations ranging from 2.7 to 27.0 mg/l detected in pus. This study investigates its potential role in treating brain abscesses originating from ear infections.
Area of Science:
- Pharmacology
- Infectious Diseases
- Neurosurgery
Background:
- Intracranial abscesses pose significant treatment challenges.
- Understanding antibiotic penetration is crucial for effective therapy.
- Ceftazidime is a third-generation cephalosporin with broad-spectrum activity.
Purpose of the Study:
- To investigate the penetration of ceftazidime into intracranial abscesses.
- To determine ceftazidime concentrations in abscess pus.
- To evaluate the potential role of ceftazidime in treating intracranial abscesses of otogenic origin.
Main Methods:
- Nine patients with intracranial abscesses received intravenous ceftazidime.
- Antibiotic concentrations in pus were measured using microbiological agar diffusion assay (12 samples) and high-performance liquid chromatography (8 samples).
- Measurements were taken at various times post-administration.
Main Results:
- Ceftazidime concentrations in intracranial abscess pus ranged from 2.7 to 27.0 mg/l.
- The data indicate measurable penetration of ceftazidime into the abscess cavity.
Conclusions:
- Ceftazidime demonstrates penetration into intracranial abscesses.
- Further evaluation is warranted for its therapeutic role in otogenic intracranial abscesses.
- These findings contribute to optimizing antibiotic strategies for brain infections.