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Cellular functions of TMEM16/anoctamin

Uhtaek Oh1,2, Jooyoung Jung3

  • 1Sensory Research Center, CRI, College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea. utoh@snu.ac.kr.

Pflugers Archiv : European Journal of Physiology
|January 27, 2016
PubMed
Summary

Calcium-activated chloride channels (CaCCs), identified as anoctamin 1 (ANO1/TMEM16A), play crucial roles in physiological functions, pain sensation, and diseases like cancer. Recent structural studies reveal their molecular gating mechanisms.

Keywords:
AnoctaminCa2+-activated Cl− channelCl− secretionNociceptionProliferationScramblaseTMEM16Tumorigenesis

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