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Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
Published on: September 22, 2023
Regional calcified plaque score evaluated by multidetector computed tomography for predicting the addition of
Teruo Sekimoto1, Yasushi Akutsu2, Yuji Hamazaki1
1Division of Cardiology, Department of Medicine, Showa University School of Medicine, Japan.
Insights
A high coronary artery calcium score from multidetector computed tomography (MDCT) can predict the need for rotational atherectomy (rotablation) during percutaneous coronary intervention (PCI). This helps in planning complex PCI procedures for calcified lesions.
Area of Science:
- Cardiovascular Imaging
- Interventional Cardiology
- Medical Diagnostics
Background:
- Rotational atherectomy (rotablation) is a technique used in percutaneous coronary intervention (PCI) for complex and calcified coronary lesions.
- Predicting the need for rotablation is crucial for optimizing PCI outcomes.
Purpose of the Study:
- To evaluate the utility of per-lesion coronary artery calcium score from multidetector computed tomography (MDCT) in predicting the requirement for rotablation during PCI.
- To establish MDCT-derived calcium scoring as a predictive tool for rotablation necessity.
Main Methods:
- Retrospective analysis of MDCT and quantitative coronary angiography (QCA) data in 116 patients undergoing first PCI for stable angina.
- Evaluation of 168 target lesions to correlate MDCT calcium scores and lesion characteristics with rotablation use.
Main Results:
- Patients requiring rotablation had significantly higher SYNTAX and total calcium scores.
- Per-lesion MDCT parameters, including calcium score (≥453) and calcification arc (≥270), predicted rotablation.
- A high per-lesion calcium score was an independent predictor of rotablation (OR 31.3, 95% CI 2.8-345), with 93% sensitivity and 88% specificity.
Conclusions:
- MDCT-derived extent of target lesion calcification is a valuable predictor of rotablation need during PCI.
- This simple marker of calcified plaque aids in procedural planning for complex coronary interventions.
Background:
Rotational atherectomy (rotablation) has been proposed as a potentially superior strategy for percutaneous coronary intervention (PCI) in complex and severely calcified lesions.
Objectives:
We hypothesized that a per-lesion coronary artery calcium score determined by multidetector computed tomography (MDCT) would be useful for predicting the requriement for rotablation during PCI.
Methods:
MDCT was performed in patients with stable angina pectoris who were scheduled for first PCI. In 116 consecutive subjects (168 target lesions) with successful PCI, MDCT and quantitative coronary angiography (QCA) data were retrospectively evaluated regarding their ability to predict rotablation.
Results:
PCI without rotablation was performed in 105 patients (154 lesions), and rotablation was added in 11 patients (14 lesions). Patients with rotablation had significantly higher SYNTAX scores (p = 0.007) and total calcium scores (p < 0.001) than those without rotablation. Per-lesion, a lesion length ≥20 mm and diameter stenosis ≥74% on QCA as well as a per-lesion calcium score ≥453 and calcification arc ≥270 in MDCT predicted rotablation. After adjustment for potential confounding variables, a high per-lesion calcium score was an independent predictor of rotablation (odds ratio 31.3, 95% confidence interval 2.8-345, p = 0.005, sensitivity 93% and specificity 88%).
Conclusion:
The extent of target lesion calcification in MDCT, a simple marker of calcified plaque, is useful for predicting the need for rotablation during PCI.
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