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Changing strategies for target therapy in gastric cancer

Suk-Young Lee1, Sang Cheul Oh1

  • 1Suk-young Lee, Sang Cheul Oh, Division of Oncology/Hematology, Department of Internal Medicine, College of Medicine, Korea University, Guro-gu, Seoul 08308, South Korea.

World Journal of Gastroenterology
|January 27, 2016
PubMed

Insights

Molecular targeted therapy, including trastuzumab, has advanced gastric cancer treatment. However, resistance and trial failures highlight the need for better patient selection and new strategies for advanced gastric cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Gastric cancer remains a leading cause of cancer mortality globally, despite incidence decreases.
  • Trastuzumab has improved survival in metastatic gastric cancer, initiating molecular targeted therapy.
  • Challenges include resistance to trastuzumab and failures of novel agents in clinical trials.

Purpose of the Study:

  • To review current molecular targeted agents and clinical trials for metastatic gastric cancer.
  • To identify limitations in existing targeted therapies.
  • To discuss future directions for advanced gastric cancer treatment.

Main Methods:

  • Literature review of approved molecular targeted agents.
  • Analysis of clinical trial data for advanced gastric cancer.
  • Discussion of molecular characteristics influencing treatment efficacy.

Main Results:

  • Trastuzumab has shown efficacy but faces resistance issues.
  • Novel targeted agents have shown limited success in gastric cancer trials.
  • Molecular profiling is crucial for selecting appropriate targeted therapies.

Conclusions:

  • Targeted therapy for advanced gastric cancer shows promise but requires optimization.
  • Overcoming resistance and improving patient selection are key challenges.
  • Future research should focus on personalized treatment strategies based on molecular profiles.
Keywords:
Advanced gastric cancerChemotherapySignal pathwayStrategyTarget therapy

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