Related Experiment Video
Updated: Mar 26, 2026

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes
Published on: January 10, 2022
Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides
Jonathan R Chekan1, Dillon P Cogan1, Satish K Nair2
1Department of Biochemistry, University of Illinois at Urbana Champaign, USA; Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, USA.
Abstract:
Research in recent years have illuminated data on the mechanisms and targets of phosphonic acid antibiotics and herbicides, including fosfomycin, glyphosate, fosmidomycin and FR900098. Here we review the current state of knowledge of the structural and biochemical characterization of resistance mechanisms against these bioactive natural products. Advances in the understanding of these resistance determinants have spurred knowledge-based campaigns aimed towards the design of derivatives that retain biological activity but are less prone to tolerance.
Related Concept Videos
Mechanism of Antibiotic Resistance in MRSA
Development of Antibiotic Resistance
Antibiotic Selection
Clinical Significance of Antibiotic Resistance
Gene Regulation in Microbial Communities: Quorum Sensing
Treatment Resistant Cancers

