Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood IL-6 is a critical trigger of depressive symptoms in a mouse model for human atopic dermatitis.

Translational psychiatry·2026
Same author

Soluble bacterial lipopeptides suppress gasdermin D-associated IL-33 release in keratinocytes and atopic dermatitis in mice.

Nature communications·2026
Same author

An arterial spin-labeled magnetic resonance imaging study of brain activation in patients with major depressive disorder during acupuncture stimulation: An exploratory study.

Psychiatry research. Neuroimaging·2026
Same author

Optimized Infrared Reflection-Absorption Spectroscopy Using Indium Tin Oxide as Thin-Film Supporting Substrates.

Applied spectroscopy·2026
Same author

Semi-quantitative tau PET approaches for Braak staging: concordance of CenTauRz and STOC with visual assessment.

Annals of nuclear medicine·2026
Same author

[SPECT Imaging].

Brain and nerve = Shinkei kenkyu no shinpo·2026

Related Experiment Video

Updated: Mar 26, 2026

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

41.0K

MRI morphometry in Alzheimer's disease.

Hiroshi Matsuda1

  • 1Integrative Brain Imaging Center, National Center of Neurology and Psychiatry 4-1-1, Ogawahigashi-cho, Kodaira, Tokyo 187-8551, Japan.

Ageing Research Reviews
|January 27, 2016
PubMed
Summary

Brain atrophy evaluation using MRI, specifically voxel-based morphometry (VBM), aids Alzheimer's disease (AD) staging and progression monitoring. This automated method offers unbiased, whole-brain analysis for clinical diagnosis.

Keywords:
Alzheimer’s diseaseGraph theoryMRIStructural connectivityVSRADVoxel-based morphometry

More Related Videos

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

1.1K
Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.7K

Related Experiment Videos

Last Updated: Mar 26, 2026

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

41.0K
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

1.1K
Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.7K

Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Diagnostics

Background:

  • Magnetic Resonance Imaging (MRI) is crucial for assessing brain atrophy in Alzheimer's disease (AD).
  • Automated volumetric software quantifies gray matter, aiding disease staging and progression monitoring.
  • Voxel-Based Morphometry (VBM) is a key technique for analyzing structural brain changes.

Purpose of the Study:

  • To highlight the utility of MRI-based brain atrophy evaluation in Alzheimer's disease (AD).
  • To discuss the application and benefits of Voxel-Based Morphometry (VBM) in clinical settings.
  • To introduce advanced methods like graph theory for analyzing structural connectivity in AD.

Main Methods:

  • Utilizing MRI for volumetric analysis of brain structures.
  • Employing automated software for gray matter quantification.
  • Applying Voxel-Based Morphometry (VBM) for unbiased, whole-brain anatomical difference assessment.
  • Exploring graph theory applications for MRI-based structural connectivity analysis.

Main Results:

  • VBM enables automated, efficient, and unbiased quantification of brain gray matter.
  • VBM software like VSRAD is established for clinical AD diagnosis, particularly in Japan.
  • Graph theory offers new avenues for analyzing AD-related changes in brain connectivity.

Conclusions:

  • MRI-based VBM is a validated and efficient method for Alzheimer's disease assessment.
  • VBM's non-biased, comprehensive approach makes it valuable for routine clinical procedures.
  • Emerging techniques like graph theory are expanding the scope of MRI analysis in neurodegenerative diseases.