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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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The Relationship of Insulin-Like Growth Factor 2 to Fetal Growth and Adiposity

Rachel Kadakia, Jami Josefson

    Hormone Research in Paediatrics
    |January 27, 2016
    PubMed

    Insights

    Insulin-like growth factor 2 (IGF-2) is crucial for growth. Research suggests IGF-2 may indicate future infant obesity risk, aiding early intervention for this public health issue.

    Area of Science:

    • Pediatric Endocrinology
    • Genetics
    • Metabolic Health

    Background:

    • Insulin-like growth factor 2 (IGF-2) is vital for human growth.
    • IGF2 gene overexpression is linked to fetal overgrowth and intrauterine programming of adipose tissue.
    • Childhood obesity is a significant public health concern, often leading to early metabolic diseases.

    Purpose of the Study:

    • To review the function of the IGF2 gene.
    • To explore proposed mechanisms linking IGF-2 to adiposity.
    • To examine current literature on IGF-2's relationship with weight and body composition in early life.

    Main Methods:

    • Literature review of studies on IGF-2, IGF2 gene, weight, and adiposity.
    • Discussion of proposed biological mechanisms.
    • Synthesis of existing research findings.

    Main Results:

    • Conflicting data exists regarding the relationship between IGF-2 and body composition.
    • IGF-2's role in fetal development and adiposity is an area of ongoing research.
    • IGF-2 may be implicated in the intrauterine programming of adipose tissue.

    Conclusions:

    • IGF-2 is essential for growth and may influence fetal adiposity.
    • Further research is needed to clarify the role of IGF-2 in infant obesity.
    • IGF-2 may emerge as a predictive marker for childhood obesity risk.

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