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Parathyroid hormone-ionized calcium dynamics over the first year of life

Atul K Sharma, Sina Gallo, Catherine A Vanstone

    Journal of Pediatric Endocrinology & Metabolism : JPEM
    |January 27, 2016
    PubMed

    Insights

    Ionized calcium (iCa) and 25-hydroxyvitamin D (25(OH)D) levels show a weak inverse relationship with parathyroid hormone (PTH) in infants. PTH concentrations naturally increase with age as infants mature physiologically.

    Area of Science:

    • Pediatric Endocrinology
    • Nutritional Science
    • Calcium and Vitamin D Metabolism

    Background:

    • Ionized calcium (iCa) is considered a primary factor influencing parathyroid hormone (PTH) levels.
    • Limited data exists on this relationship specifically within infant populations.

    Purpose of the Study:

    • To investigate the relationship between ionized calcium (iCa) and parathyroid hormone (PTH) in healthy, breastfed infants.
    • To assess the influence of 25-hydroxyvitamin D (25(OH)D) and age on PTH concentrations.

    Main Methods:

    • An ancillary study utilizing data from a vitamin D3 dose-response trial in infants.
    • Measurements of iCa, phosphorus, PTH, and 25(OH)D were taken at multiple time points from 1 to 12 months.
    • Statistical analysis included Pearson correlation and mixed-effects regression models to account for repeated measures.

    Main Results:

    • No significant correlation was found between iCa and PTH at individual measurement points.
    • A weak negative correlation between iCa and PTH was observed after accounting for repeated measures (slope -5.25).
    • PTH levels decreased with increasing 25(OH)D and increased with age (6-12 months).

    Conclusions:

    • A weak inverse relationship exists between ionized calcium and parathyroid hormone in infants.
    • Parathyroid hormone levels increase with age, suggesting physiological maturation.
    • Findings contribute to understanding calcium-PTH dynamics during early development.
    Abstract

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