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[Case-control study of expansion of heart cavity and great vessel diameters in acromegaly]

Xiaopeng Guo1, Lu Gao1, Shuo Zhang1

  • 1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Zhonghua Yi Xue Za Zhi
|January 28, 2016
PubMed

Insights

Acromegaly patients exhibit enlarged heart cavities and great vessels. The duration of the disease, not hormone levels, is the primary risk factor for this expansion.

Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Imaging

Background:

  • Acromegaly, a disorder caused by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1), is associated with cardiovascular complications.
  • Cardiac chamber and great vessel dimensions may be altered in acromegaly, but risk factors require further investigation.

Purpose of the Study:

  • To investigate alterations in heart cavity and great vessel diameters in acromegalic patients.
  • To identify risk factors associated with these dimensional changes.

Main Methods:

  • A case-control study involving 92 acromegalic patients and 92 healthy controls.
  • Echocardiography and endocrine hormone level assessments were performed.
  • Binary logistic regression analysis was used to determine risk factors for vessel diameter expansion.

Main Results:

  • Acromegalic patients showed significantly larger left ventricle end-diastolic diameter (LVEDD), left ventricle end-systolic diameter (LVESD), left atrium longitudinal dimension (LALD), right ventricle longitudinal dimension (RVLD), aortic root dimension (AORD), ascending aorta (AA), and main pulmonary artery (MPA) compared to controls (P<0.05).
  • Disease duration was identified as a statistically significant risk factor for the expansion of great vessel diameters (OR=1.011).
  • A predictive formula was derived: logit (ADE) = -3.420 + 0.011 × duration of disease.

Conclusions:

  • Acromegaly is associated with increased heart cavity and great vessel diameters.
  • The duration of the disease is the primary risk factor for the expansion of great vessel diameters, independent of serum GH and IGF-1 levels.
Abstract

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