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Granulomatous eruption after BCG vaccine immunotherapy for malignant melanoma
C R Shea1, M J Imber, T G Cropley
1Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
Journal of the American Academy of Dermatology
|November 1, 1989
Abstract:
In a patient receiving intralesional bacille Calmette-Guérin vaccine injections for recurrent cutaneous metastases of malignant melanoma of the right leg, a striking eruption developed on that limb only. The eruption consisted of multiple 1 to 2 mm, reddish brown, flat-topped papules, with confluence into plaques. Histopathologic examination showed multiple tuberculoid granulomas within the papillary and reticular dermis; special stains and cultures were negative for mycobacteria.