Related Experiment Video

Updated: Mar 26, 2026

Author Spotlight: Advancing Antidiarrheal Research with the Drosophila Model
07:38

Author Spotlight: Advancing Antidiarrheal Research with the Drosophila Model

Published on: November 17, 2023

2.2K

Effect of Oral Dimenhydrinate in Children with Acute Gastroenteritis: A Clinical Trial

Simin Gheini1, Somaieh Ameli1, Jamal Hoseini2

  • 1Department of Pediatrics, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Oman Medical Journal
|January 28, 2016
PubMed

Insights

Oral dimenhydrinate (DH) did not reduce vomiting in children with acute gastroenteritis. However, DH effectively reduced diarrhea frequency and duration, warranting further investigation for this common childhood illness.

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Pharmacology

Background:

  • Acute gastroenteritis is a leading cause of mortality in children.
  • Vomiting is a prevalent symptom in the early stages of acute gastroenteritis.

Purpose of the Study:

  • To evaluate the efficacy of oral dimenhydrinate (DH) in controlling vomiting associated with acute gastroenteritis in pediatric patients.
  • To assess the impact of DH on other symptoms and outcomes of acute gastroenteritis in children.

Main Methods:

  • A double-blind, randomized, placebo-controlled clinical trial involving 200 children aged 1-12 years.
  • Participants received either oral DH (1 mg/kg every 6 hours) or a placebo.
  • Outcomes including vomiting, diarrhea, side effects, and parent satisfaction were compared at 24 hours, 7 days, and 14 days post-discharge.

Main Results:

  • No statistically significant difference in the mean number of vomiting episodes between the DH and placebo groups (4.4±2.5 vs 4.4±2.1).
  • A significant reduction in the mean number of diarrhea episodes in the DH group (7.4±3.2) compared to the placebo group (10.1±2.8).
  • Significant differences were observed in diarrhea duration, side effects, re-visit rates, and parental satisfaction between the groups (p>0.050).

Conclusions:

  • Oral dimenhydrinate is not effective in reducing the frequency or duration of vomiting in children with acute gastroenteritis.
  • DH demonstrated efficacy in decreasing the frequency and duration of diarrhea in pediatric patients with acute gastroenteritis.
  • Further research is recommended to explore the benefits of DH in managing diarrhea in acute gastroenteritis and its associated outcomes.
Abstract

Keywords:
ChildrenDimenhydrinateGastroenteritisVomiting

More Related Videos

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture05:33

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture

Published on: August 4, 2023

2.5K
Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans07:23

Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans

Published on: December 3, 2019

16.3K

Related Concept Videos

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
538
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
697
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
1.7K
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
863
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
794
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
1.0K